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New Treatment for Constipation

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  • New Treatment for Constipation

    Since we know that IC flares often get worse during periods of constipation and, of course, that some medications we take can make constipation even more challenging, this news offers new hope for those IC'ers who suffer with chronic, painful constipation. Hey, what can I say? I'm willing to talk about anything, including our bowel health! :::grins widely::: - Jill Osborne

    Researchers Find New Treatment for Constipation
    Released: 5/6/2011 1:45 PM EDT
    Embargo expired: 5/10/2011 9:30 AM EDT
    Source: Mayo Clinic

    Newswise — ROCHESTER, Minn. - Constipation is definitely not a glamorous topic. In reality, it affects nearly 30 million Americans and costs more than $1 billion annually to evaluate and treat. While not often life threatening, the pain, bloating, discomfort, and straining associated with constipation lead sufferers to focus on one thing - relief. Mayo Clinic researchers recently had success in the clinical trial of a new medication shown to provide relief from constipation in a way that capitalizes on the body’s natural processes.

    The drug, called A3309, targets bile acid recycling in the body. Bile acids, created in the liver and released into the digestive system, aid in breaking down fats and absorbing them into the body. Bile acids also are natural laxatives that promote bowel movements by softening stool and speeding up how fast stool moves through the colon. During digestion, most bile acids are absorbed back into the blood in the lower small intestines for recycling, letting very little bile acids to leak into the colon to help facilitate bowel movements. A3309 works by inhibiting bile acid absorption in the small intestines, allowing more bile acids to enter the colon to stimulate bowel movements.

    “The new medication is a novel approach which allows the delivery to the colon of normal substances produced by the patient’s own liver to induce a laxative effect,” says Michael Camilleri, M.D., a gastroenterologist and Atherton and Winifred W. Bean Professor at Mayo Clinic and the study’s lead author.

    In a Phase II, randomized, double-blind, placebo-controlled study, the Mayo Clinic research team tested the effectiveness of A3309 for two weeks in patients with constipation. The study yielded promising results. The drug sped up the movement of stool through the colon. Patients with constipation who took A3309, compared to those who received placebo, reported significantly less straining and softer stool during bowel movements, says researcher Banny Wong, M.D.

    The main side effect of A3309 was abdominal discomfort and pain. Dr. Wong says this occurred mainly before a bowel movement, after which the pain and discomfort usually went away.

    According to Dr. Wong, the next step in the drug’s development will be Phase III studies that will involve more people and a longer treatment duration.
    Dr. Wong is sharing the study’s findings at the 2011 Digestive Disease Week international conference May 7-10 at McCormick Place in Chicago.

    The study’s other researchers are Sanna McKinzie; Duane Burton; and Alan R. Zinsmeister, Ph.D., of Mayo Clinic in Rochester, Minn.; and Hans Graffner, M.D., of Albireo, Gothenburg, Sweden.

    About Mayo Clinic
    Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit and
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  • #2
    Astra Zeneca is in clinical trials for a new drug for constipation as well. The trials are going on in Canada and look very promising.


    • #3
      Forgot to add that this new Astra Zeneca drug is for opiod induced constipation.


      • #4

        I have constipation from opiod use and use magnesium before bed

        works just fine


        • #5
          My son's body produces too much bile and takes a drug daily to slow things down from going through his system too fast.

          I once game him red gator aid and it came out theother end red in color in less than an hour.

          Finding out he had too much bile was a god send fro him, it gave him his life back.

          My are with you all. May you all find a way to peace and joy in your lives.


          • #6
            question about the new medication

            I don't have a gall bladder so would the new drug A3309 work for me? Does the liver also produce bile. I am confused? I have opoid induced constipation myself. It sounds like the astra zeneca might be the way to go.
            GO TO:
            lumbar pain,depression,periphreal neuropathy,Insomnia,IBS
            for pain-tramadol ER 200 mgs (once a day),for break-thru pain-talwin(as needed),for periphreal nueropathy-Lyrica 150 mgs (3 times a day),for insomnia-ambien10mgs,for hot flashes- estradiol (estrogen),for IBS-Questran (one packet a day),for depression-paxil (80 mgs)=two 40 mgs a day

            *Bladder and Urethra removed (Radical Cystectomy)-August 2012
            *Vaginal Prolapse surgery, ovaries removed and Interstim removed 2012June 2012
            *Cauterization of the bladder lining-1992-i don't know the technical term
            *Bladder distension and cauterization-1992
            *Gallbladder removal-1995-gall stones
            *Hysterectomy-1998-still have ovaries
            *Interstim trial-2002
            *Interstim implant-2002
            *Trial pain pump did not work
            *spinal injections-2009 (once with 1 injection and a second time with 6 injections)


            • #7
              I eat blueberries and kiwi fruit to stay regular.It works for me.