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Cyclosporine Case Study in Patient with IC & Sjogren's Syndrome

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  • Cyclosporine Case Study in Patient with IC & Sjogren's Syndrome

    This small case study shares experience with a sjogren's syndrome and interstitial cystitis. Her clinicians gave her a low dose of cyclosporine after other available treatments failed. Her bladder showed signs of improvement suggesting, yet again, that cyclosporine is a viable option for patients who are not responding to other therapies. Cyclosporine is noted in the newly released AUA Guidelines for the Treatment of IC/BPS. - Jill

    Emmungil H, Kalfa M, Zihni FY, Karabulut G, Keser G, Sen S, Aksu K. Interstitial cystitis: a rare manifestation of primary Sjögren's syndrome, successfully treated with low dose cyclosporine. Rheumatol Int. 2011 Jan 22.

    Source - Department of Internal Medicine, Division of Rheumatology, Ege University School of Medicine Hospital, 35100, Bornova, Izmir, Turkey,

    Chronic interstitial cystitis (IC), mostly affecting middle-aged women, is a very rare manifestation of primary Sjögren's syndrome (pSS). Hereby, we report a 42-year-old woman with pSS, presenting with dysuria, urinary frequency, and suprapubic pain. She was diagnosed to have chronic IC, based upon the cystoscopic biopsy finding of chronic inflammation in the bladder wall. Systemic corticosteroid and azathioprine treatments together with local intravesical therapies were not effective. Therefore, cyclosporine (CSA) therapy was initiated. Initial low dose of CSA (1.5 mg/kg/d) improved the symptoms of the patient, with no requirement for dose increment. After 4 months of therapy, control cystoscopic biopsy showed that bladder inflammation regressed and IC improved. This case suggests that even low doses of CSA may be beneficial for treating chronic IC associated with pSS syndrome.
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