Hi everyone, I used to take Depo estradiol injections and had fewer bladder problems for several years on that therapy. Then ins stopped paying for them. I am wondering if anyone else has had experience with injections as opposed to patches or pills? If the expense hasn't gotten out of sight for injections now I am thinking of trying them again to benefit my bladder lining. The reasoning behind orig injections by that gnecological group ws that everyone doesn't assimalate oral meds well and strong hormones benefit bladder linings. I am at the point with symptoms I am open to try anything as I can't take oral Premarin without making symptoms worse. Thanks Pentimento