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Cidofovir Instillation dramatically improved IC symptoms in ulcerative IC patients

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  • Cidofovir Instillation dramatically improved IC symptoms in ulcerative IC patients

    Resent research has found evidence of a polyomavirus associated with ulcerative interstitial cystitis:

    A Case Control Study Reveals that Polyomaviruria Is Significantly Associated with Interstitial Cystitis and Vesical Ulceration
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556646/


    In keeping with this, a study which used an antiviral named Cidofovir was instilled in patients. Not only was nocturia reduced, but the results were sustained for 8 months after just 3 instillations with Cidofovir. Here I provide a link to the study, and, next an important quote from it:

    Decreased Viral Load and Symptoms of Polyomavirus-Associated Chronic Interstitial Cystitis after Intravesical Cidofovir Treatment
    Damon P. Eisen Ian R. Fraser Linda M. Sung Moira Finlay Scott Bowden Helen O'Connell
    Clinical Infectious Diseases, Volume 48, Issue 9, 1 May 2009, Pages e86–e88, https://doi.org/10.1086/597827

    Link: https://academic.oup.com/cid/article/48/9/e86/412161e

    Here's a quote from the study to show it's level of success
    A trial of intravesical cidofovir (375 mg weekly) was begun 5 weeks after the cessation of leflunomide treatment, because the IC symptoms continued unabated. With intravesical cidofovir treatment, there was considerable improvement in the symptoms. After 2 doses of cidofovir, the patient had decreased frequency of nocturia and was able to void every 2.5 h. This improvement was sustained for 8 months after the third dose of cidofovir.
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