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do OAB drugs really work?

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  • do OAB drugs really work?

    I have tried several OAB drugs with little to no success (detrol, vesicare, cardura to name a few). So I googled "best overactive bladder medications" and came up with a Consumer Reports overview of the 6 overactive bladder meds that are being marketed today. The thing that I found the most interesting was that it said most overactive bladder meds reduce frequency by on average 2-3 voids a day. When you are voiding 20 times in 24 hours on a GOOD day, reducing the amount of times you void by ONLY 2-3 times really seems insignificant. Plus, I have found a lot of the side effects of these meds to be pretty bothersome.

    So my question for people on OAB meds, do these significantly reduce the amount of times you void?

  • #2
    How long did you take them before you felt they weren't helping. Sometimes it can take at least weeks for a medication to become effective.

    Warm hugs,
    Donna
    Stay safe


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    • #3
      I have tried most of them.

      I think they do work because on me I go from going every 30 mins to none at all.

      I have retention problems so this type of meds make them much worse, but my understanding is that it reduces the spasms your bladder has so reduces the urge to go.

      I would think other's will jump in here because I am sure many people get better effect than just reducing-3 x's per day.

      Also the tests would have been run on people with OAB, not IC, so results my be different and in any case results will very greatly from person to person.

      MG
      My are with you all. May you all find a way to peace and joy in your lives.

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      • #4
        I didn't notice a significant reduction, but there was an improvement. My frequency issues fluctuated so much to begin with it was hard to tell if the OAB med was doing anything, or I was just going less on my own.

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        • #5
          I think they are probably working for me. Before I was diagnosed, the first uro I went to see just gave me some samples of Sanctura and told me to come back in 6 weeks. It did seem to help but it caused some retention for me and very dry mouth. I went off it when the second uro I saw thought I might have kidney stones and definitely noticed my frequency went back up again. I'm currently on 10mg of VESIcare per day and I know it's working because I ran out of the sample packs I had and was right back at feeling like my bladder was ALWAYS full and running to the bathroom every 20 minutes. Now, the urge is still there but I really feel it's reduced enough that I can wait a hour and a half or so between voids now. Frequency is my main issue though so that extra hour of not feeling like I'm going to pee RIGHT NOW allows me to get out of the house and do some things I couldn't before so that's huge for me.
          Diagnosed with IC in April 2011. Medications and IC treatments did not help, diagnosed with PFD in September of 2013. Still searching for answers as to why I have never-ending frequency/urgency issues.

          Current medications/treatments:
          Pelvic physical therapy, valium suppositories, b and o suppositories, acupuncture, probiotics, magnesium, epsom salt baths

          Previous medications/treatments:
          Elmiron, Hydroxizine, Elavil, VESIcare, Series of rescue instillations using Elmiron, water, lidocaine, & sodium bicarb and self-cathing with instills as needed, D-mannose, Glucosamine, Hyophen (generic Prosed), Colostrum, IC diet, PTNS, chiropractic treatments, Desert Harvest Aloe Vera, CystoProtek

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          • #6
            Hi, Sabrina00 ~

            Unfortunately I've tried Vesicare and had horrible retention. I've also tried Urelle with the same results. This was in my early diagnosis and trying anything to help with the pain/frequency/urgency.

            Hope you find what works well for you.
            Never heard of IC til suspected....Never knew so many suffer from it. Praying for a cure. I've found answers...so can you...keep the hope.

            11/2007 IC Symptoms began during recovery of surgery for bladder susp & hysto: painful/urge/freq urination up to 50 times a day, pain walking, even water hurts.
            8/2009 Susp IC; 1/2010 Treatment began; 2/2010 Diag PFD, PT, Surg remove mesh; 5/2010 Surg, 2nd bladder repair, vag vault/sm int prolapse repair, IC confirmed in surg; 7/2010 Diag Candida Esophagitis, Gastritis, Diviticulosis, Gallstones,
            8/2010 Surg gallbladder
            TREATMENTS (updated 4/15)
            IC Diet since 8/2009 (Able to vary 4/15)
            Heparin/Lidocaine/Bicarb/Kenalog Instills 1xDay
            Aloe Vera Capsules, (2) 2xDay, Loratadine 1xDay
            Pantoprazole, Prelief, Pyridium up to 3xDay, Premarin Cream 3xWeek
            *DISCONTINUED since feeling better: Celexa 10mg daily*, Fiber supp*,
            Gabapentin 12/2011 worked well *, Macrodantin 100mg after instill*, Probiotics*, PT-PFD*, Valium Vag Suppositories: Cyclo/diaz/lido, 10/5/62.5mg *
            PROB MEDS: Elavil, up to 50mg 1/2011 ret&hbp, Urelle ret, Vesicare ret

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            • #7
              Initially I was prescribed Ditropan XL. This worked well for me for several years. After a bad UTI 5 years ago, my bladder just would not settle back down. My Uro switched me to Enablex, and it works great for me.

              When I was first diagnosed, the only scripts I was given were for Ditropan XL and Tofranil (Imipramine). After finding this site, I asked for a prescription for Atarax. Presently I am also having to take Urelle 3 to 4 times per day.

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              • #8
                I took OAB meds before I was diagnosed with IC and they did not help. I'm assuming everyone is different so it will be your body personally on how the react. Its worth a try if you haven't done it before.
                Diagnosis: IC '09, vulvodynia '10, fructose intolerance '06, GERD '06, fibromyalgia '09, IBS '10 and TMJ '09, PCOS '11, genital herpes '12

                Current Meds: Butrans patch, welbutrin, lamictol, geodon, xanax, aldactone, linzess, topimax, trazadone and diflucan as needed.

                Meds tried before: Elmiron, elavil, antibiotics, welbutrin, cymbalta, prozac, nerve blocks, instills, nyastatin, flexerol, percocet, naproxen (which was what I was given for pain for years).

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                • #9
                  They definitely helped me a couple years ago, it was the difference between going every 10 minutes to going every 45 minutes.
                  Now, it doesn't seem to make a significant difference if I'm on them or not, as I still have severe spasms all the time. The thing that does help is knowing you have extra support in that area, and can try to retrain your bladder.
                  Give the meds at least two months to work, and try to retrain at the same time, it might make a big improvement.
                  21 years old
                  dx: severe OAB, mild/moderate IC, depression, PTSD, agoraphobia, chronic fatigue, IBS, peripheral neuropathy

                  ♥ looking for a way or medication to help stop spasms ♥

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                  • #10
                    I'm on Vesicare and Rapaflo these two meds together have helped me greatly.
                    IC diagnosis 3 weeks ago.
                    Vesicare 10 mg once daily
                    IBS and Gerd-Zegerid
                    IC diet
                    Elmiron 100 mg three daily
                    Hydroxyzine 25 mg at night
                    Amitriptyline 10mg at night
                    Diovan 60/12.5 daily
                    Topral 50 mg daily
                    Zoloft 100 mg at night
                    Klonopin .5 twice daily

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                    • #11
                      I've been on a 3 month Detrol spree in the past. After that, not just the frequency was gone, my flares stopped altogether. Yay!

                      Unfortunately, they returned after 1.5 years of remission. Detrol doesn't seem to work anymore. Neither do other OAB meds.
                      Not diagnosed yet

                      More than a decade of 'bladder issues'
                      Main symptoms: burning pain in urethra, urgency, frequency
                      Triggers: Alcohol, carbonated drinks, tight jeans, synthetic underwear, stress, dehydration
                      Tests: zillion negative cultures, a cysto-hydro with biopsy, two urodynamics, several cysto's and ultrasounds, a sphincter electromyogram
                      Starting physical therapy soon

                      Getting married 7/7/2012

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                      • #12
                        In the early going Ditropan,Detrol LA and Vesicare did nothing for my OAB and Enablex caused terrible retention for me. I was mis diagnosed with OAB,my disease is IC and OAB meds do not work for me. I have been on Elmiron on and off since June 2008.Frequency was the last symptom to calm down.

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                        • #13
                          The correct question is, "Do OAB bladdere meds work for me?" Trial and error is the only way to find what works for you. I think they help me. Elmiron does too. Neither works alone, I need both and then do reasonably well.
                          What helps
                          Elmiron 200 mg bid
                          Wellbutrin XL anxiety and depression
                          Oxybutynin ER 10 mg
                          Yoga


                          tried and failed
                          Cardura, Hytrin, Flomax, Prosed DS, Vesicare, Pyridium, Cystoprotek (caused GI problems), Lyrica, Pamelor

                          "We can't wait until the storm is over. We need to learn to dance in the rain."

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                          • #14
                            I have found that they are helpful in reducing that horrible "twitching" feeling near my urethra that leaves me sitting on the toilet for 5 minutes after I stop peeing. They don't seem to reduce the number of times I go but it is easier when I go, if that makes sense. Then again I have never had severe frequency (about once an hour, which seems like its not bad after reading these forums).
                            Medications and Supplements:
                            BladderQ
                            Pyridium
                            D-Mannose powder
                            Cranmax

                            Lifestyle:
                            Lacto-ovo-vegetarian and IC diet
                            Meditation
                            Positive mental attitude!

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